CORRELATION BETWEEN RS6265 SNP IN BDNF AND THE CONTEXT OF INVOLVEMENT IN TYPE II DIABETES IN IRAQI PATIENTS
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Wiad Lek. 2022;75(4 pt 1):787-790. doi: 10.36740/WLek202204107.
OBJECTIVE: The aim: In this study, we investigated the possible link between the G196A polymorphism of the BDNF gene and DM in Iraqi patients.
PATIENTS AND METHODS: Materials and methods: Using the PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) approach, 100 subjects were genotyped for the SNP G196A of the BDNF gene, 50 as DM and 50 as controls, age- sex and ethnically matched healthy controls. Analysis of covariance (ANCOVA) was used to assess the association of this polymorphism, and genotypic frequencies were compared between patients and healthy controls.
RESULTS: Results: Our results show that patients with AG (Val-Met) genotype had 40% of total DM patients compared to those with GG (Val-Val) genotypes. Therefore, we concluded that as a future aspect of the report, the work can be further extended to the proteomic level where the corresponding change occurred due to the mutation in the protein can be further detected at the structural level and functional.
CONCLUSION: Conclusions: The conclusion of our result was that any patient with covid-19 must be followed for at least 1 month after recovery to be informed of post-Covid symptoms, especially the male sex.